{"id":26691,"date":"2025-03-02T09:19:00","date_gmt":"2025-03-02T00:19:00","guid":{"rendered":"https:\/\/sakuda-clinic.com\/doctor\/?p=26691"},"modified":"2025-02-24T21:47:47","modified_gmt":"2025-02-24T12:47:47","slug":"%e9%ab%98%e3%82%ab%e3%83%aa%e3%82%a6%e3%83%a0%e8%a1%80%e7%97%87%e3%81%a8%e6%85%a2%e6%80%a7%e8%85%8e%e8%87%93%e7%97%85%ef%bc%88ckd%ef%bc%89","status":"publish","type":"post","link":"https:\/\/sakuda-clinic.com\/doctor\/?p=26691","title":{"rendered":"\u9ad8\u30ab\u30ea\u30a6\u30e0\u8840\u75c7\u3068\u6162\u6027\u814e\u81d3\u75c5\uff08CKD\uff09"},"content":{"rendered":"\n

\u3000<\/p>\n\n\n\n

\u9ad8\u30ab\u30ea\u30a6\u30e0\u8840\u75c7\u306f\u3001\u6162\u6027\u814e\u81d3\u75c5\uff08CKD\uff09\u306e\u65b9\u306b\u6bd4\u8f03\u7684\u3088\u304f\u307f\u3089\u308c\u308b\u96fb\u89e3\u8cea\u7570\u5e38\u3067\u3059\u3002<\/p>\n\n\n\n

\u63a8\u8a08\u3067\u306f\u3001CKD\u60a3\u8005\u306e14\u301c20\uff05\u306b\u751f\u3058\u3001\u814e\u6a5f\u80fd\u306e\u4f4e\u4e0b\u306b\u5fdc\u3058\u3066\u5897\u52a0\u3059\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u30ab\u30ea\u30a6\u30e0\u306f\u7b4b\u8089\u3084\u795e\u7d4c\u306e\u6d3b\u52d5\u306b\u4e0d\u53ef\u6b20\u3067\u3059\u304c\u3001\u904e\u5270\u306b\u306a\u308b\u3068\u81f4\u6b7b\u7684\u306a\u4e0d\u6574\u8108\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

CKD\u304c\u9032\u3080\u3068\u3001\u5c3f\u7d30\u7ba1\u3067\u306e\u30ab\u30ea\u30a6\u30e0\u6392\u6cc4\u3084\u30db\u30eb\u30e2\u30f3\u8abf\u6574\u304c\u5341\u5206\u306b\u50cd\u304b\u306a\u304f\u306a\u308a\u3001\u9ad8\u30ab\u30ea\u30a6\u30e0\u8840\u75c7\u304c\u8d77\u3053\u308a\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u305d\u306e\u5bfe\u7b56\u3068\u3057\u3066\u3001\u5f93\u6765\u306f\u30ab\u30ea\u30a6\u30e0\u6442\u53d6\u91cf\u306e\u5236\u9650\u3084\u5229\u5c3f\u85ac\u306e\u4f7f\u7528\u3001\u3042\u308b\u3044\u306f\u30ab\u30ea\u30a6\u30e0\u6fc3\u5ea6\u3092\u4e0a\u6607\u3055\u305b\u308b\u85ac\u5264\uff08RAS\u963b\u5bb3\u85ac\u306a\u3069\uff09\u306e\u6e1b\u91cf\u304c\u5b9f\u65bd\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3055\u3089\u306b\u3001\u53e4\u304f\u304b\u3089\u7528\u3044\u3089\u308c\u3066\u304d\u305f\u30ab\u30ea\u30a6\u30e0\u7d50\u5408\u6a39\u8102\u300cSPS\uff08\u30dd\u30ea\u30b9\u30c1\u30ec\u30f3\u30b9\u30eb\u30db\u30f3\u9178\u30ca\u30c8\u30ea\u30a6\u30e0\uff09\u300d\u306f\u30011958\u5e74\u306b\u627f\u8a8d\u3092\u5f97\u305f\u6b74\u53f2\u3042\u308b\u85ac\u5264\u3067\u3059\u3002<\/p>\n\n\n\n

\u4f8b\u3048\u3070\u300130g\u670d\u7528\u3059\u308b\u3068\u5e73\u5747\u7d041.0mmol\/L\u300160g\u670d\u7528\u3059\u308b\u3068\u7d041.7mmol\/L\u306e\u30ab\u30ea\u30a6\u30e0\u6e1b\u5c11\u304c\u5f97\u3089\u308c\u305f\u3068\u306e\u5831\u544a\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u3057\u304b\u3057\u3001\u4fbf\u79d8\u306e\u307b\u304b\u3001\u307e\u308c\u306b\u91cd\u5ea6\u306e\u6d88\u5316\u7ba1\u58ca\u6b7b\uff08\u3068\u304f\u306b\u30bd\u30eb\u30d3\u30c8\u30fc\u30eb\u914d\u5408\u6642\uff09\u306a\u3069\u306e\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u8fd1\u5e74\u3001\u65b0\u3057\u3044\u30ab\u30ea\u30a6\u30e0\u7d50\u5408\u85ac\u304c\u81e8\u5e8a\u3067\u4f7f\u308f\u308c\u59cb\u3081\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u30d1\u30c1\u30ed\u30de\u30fc\uff08Patiromer\uff09\u306f\u3001\u4e3b\u306b\u5927\u8178\u3067\u30ab\u30ea\u30a6\u30e0\u3068\u7d50\u5408\u3057\u6392\u6cc4\u3092\u4fc3\u3059\u85ac\u3067\u3059\u3002<\/p>\n\n\n\n

\u5927\u898f\u6a21\u8a66\u9a13AMETHYST-DN\u3067\u306f\u3001\u814e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u305f\u7cd6\u5c3f\u75c5\u60a3\u8005\uff08\u63a8\u7b97\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf15\u301c59mL\/min\/1.73m^2\uff09\u3092\u5bfe\u8c61\u306b\u6295\u4e0e\u3057\u30011\u5e74\u3092\u901a\u3058\u3066\u5b89\u5b9a\u3057\u305f\u30ab\u30ea\u30a6\u30e0\u4f4e\u4e0b\u52b9\u679c\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u526f\u4f5c\u7528\u3068\u3057\u3066\u306f\u4fbf\u79d8\u3084\u4f4e\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u8840\u75c7\uff08\u7d047.2\uff05\uff09\u306a\u3069\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u5168\u4f53\u7684\u306b\u306f\u826f\u597d\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u540c\u3058\u304f\u3001SZC\uff08Sodium Zirconium Cyclosilicate\uff09\u306f\u7d50\u6676\u69cb\u9020\u304c\u30ab\u30ea\u30a6\u30e0\u306b\u9078\u629e\u7684\u306b\u7d50\u5408\u3059\u308b\u7279\u9577\u3092\u6301\u3061\u3001\u5e73\u57472.2\u6642\u9593\u3068\u3044\u3046\u901f\u3055\u3067\u30ab\u30ea\u30a6\u30e0\u3092\u6b63\u5e38\u5316\u3057\u305f\u30c7\u30fc\u30bf\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08HARMONIZE\u8a66\u9a13\uff09\u3002<\/p>\n\n\n\n

\u305f\u3060\u3057\u30011\u56de10g\u3042\u305f\u308a\u30ca\u30c8\u30ea\u30a6\u30e0\u3092800mg\u542b\u3080\u305f\u3081\u3001\u6d6e\u816b\u3084\u8840\u5727\u4e0a\u6607\u3078\u306e\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n

\u3044\u305a\u308c\u306e\u85ac\u5264\u3082\u65b0\u3057\u3044\u9078\u629e\u80a2\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u4e00\u65b9\u3001\u4fdd\u967a\u306e\u9069\u7528\u72b6\u6cc1\u3084\u4fa1\u683c\u306e\u9ad8\u3055\uff08\u30a2\u30e1\u30ea\u30ab\u306e\u4f8b\uff1a\u30d1\u30c1\u30ed\u30de\u30fc\u304c\u6708\u3042\u305f\u308a1000\u30c9\u30eb\u8d85\uff09\u306b\u3088\u308a\u666e\u53ca\u304c\u9032\u307f\u306b\u304f\u3044\u9762\u3082\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u5065\u5eb7\u306a\u4eba\u306b\u306f\u91ce\u83dc\u3084\u679c\u7269\u306e\u3088\u3046\u306a\u30ab\u30ea\u30a6\u30e0\u8c4a\u5bcc\u306a\u98df\u6750\u304c\u597d\u307e\u3057\u3044\u4e00\u65b9\u3001CKD\u306e\u65b9\u306b\u3068\u3063\u3066\u306f\u904e\u5270\u30ab\u30ea\u30a6\u30e0\u306e\u30ea\u30b9\u30af\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u3057\u304b\u3057\u3001\u91ce\u83dc\u3084\u679c\u7269\u306b\u306f\u98df\u7269\u7e4a\u7dad\u3084\u30a2\u30eb\u30ab\u30ea\u6210\u5206\u304c\u591a\u304f\u542b\u307e\u308c\u3001\u814e\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3084\u9aa8\u306e\u5065\u5eb7\u7dad\u6301\u306b\u826f\u3044\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u5b9f\u969b\u3001\u3044\u304f\u3064\u304b\u306e\u89b3\u5bdf\u7814\u7a76\u3067\u306f\u98df\u4e8b\u4e2d\u306e\u30ab\u30ea\u30a6\u30e0\u6442\u53d6\u304c\u5c11\u306a\u3044\u3068CKD\u60aa\u5316\u3084\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u3044\u3046\u30c7\u30fc\u30bf\u304c\u3042\u308a\u3001\u4e00\u65b9\u3067\u660e\u78ba\u306a\u56e0\u679c\u95a2\u4fc2\u306f\u307e\u3060\u65ad\u5b9a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n

RCT\uff08\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\uff09\u3068\u3057\u3066\u306f\u3001\u305f\u3068\u3048\u3070CKD\u30b9\u30c6\u30fc\u30b84\u306e\u88ab\u9a13\u8005\u304c\u91ce\u83dc\u3084\u679c\u7269\u3092\u591a\u304f\u6442\u308b\u3053\u3068\u3067\u8840\u6db2\u4e2d\u306e\u91cd\u70ad\u9178\u6fc3\u5ea6\u304c\u6539\u5584\u3057\u3001\u814e\u6a5f\u80fd\u306e\u6025\u6fc0\u306a\u4f4e\u4e0b\u304c\u8d77\u3053\u3089\u306a\u304b\u3063\u305f\u3068\u3044\u3046\u7d50\u679c\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u7b4b\u8089\u304c\u53ce\u7e2e\u3059\u308b\u3068\u7d30\u80de\u5185\u306e\u30ab\u30ea\u30a6\u30e0\u304c\u4e00\u6642\u7684\u306b\u8840\u4e2d\u3078\u653e\u51fa\u3055\u308c\u3001\u904b\u52d5\u4e2d\u306b\u306f\u30ab\u30ea\u30a6\u30e0\u304c\u6025\u4e0a\u6607\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u4f8b\u3048\u3070\u3001\u6fc0\u3057\u3044\u77ed\u8ddd\u96e2\u8d70\u306e\u7814\u7a76\u3067\u306f\u8840\u6e05\u30ab\u30ea\u30a6\u30e0\u304c\u304a\u3088\u305d2\u500d\u306b\u4e0a\u304c\u3063\u305f\u3068\u3044\u3046\u5831\u544a\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u3057\u304b\u3057\u904b\u52d5\u7d42\u4e86\u5f8c\u306b\u306f\u30ca\u30c8\u30ea\u30a6\u30e0\u30dd\u30f3\u30d7\uff08Na+<\/sup>\/K+<\/sup>-ATPase\uff09\u304c\u6d3b\u6027\u5316\u3055\u308c\u3001\u30ab\u30ea\u30a6\u30e0\u306f\u518d\u3073\u7d30\u80de\u5185\u3078\u53d6\u308a\u8fbc\u307e\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u9577\u671f\u7684\u306b\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u6539\u5584\u3084\u30dd\u30f3\u30d7\u91cf\u306e\u5897\u52a0\u304c\u671f\u5f85\u3055\u308c\u308b\u305f\u3081\u3001\u6162\u6027\u7684\u306a\u9ad8\u30ab\u30ea\u30a6\u30e0\u8840\u75c7\u4e88\u9632\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u900f\u6790\u4e2d\u306e\u904b\u52d5\u3067\u306f\u30ab\u30ea\u30a6\u30e0\u9664\u53bb\u304c\u5411\u4e0a\u3057\u305f\u3068\u3059\u308b\u4e00\u90e8\u7814\u7a76\u3082\u3042\u308a\u3001\u5c11\u306a\u304f\u3068\u3082\u904b\u52d5\u306e\u591a\u5f69\u306a\u5065\u5eb7\u30e1\u30ea\u30c3\u30c8\u3092\u8003\u3048\u308b\u3068\u3001\u533b\u7642\u5f93\u4e8b\u8005\u306e\u6307\u5c0e\u306e\u3082\u3068\u5b89\u5168\u306b\u53d6\u308a\u5165\u308c\u308b\u4fa1\u5024\u304c\u3042\u308a\u305d\u3046\u3067\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u9ad8\u30ab\u30ea\u30a6\u30e0\u8840\u75c7\u306f\u5fc3\u81d3\u3078\u306e\u8ca0\u62c5\u306e\u307f\u306a\u3089\u305a\u3001\u6cbb\u7642\u85ac\u306e\u9078\u629e\u3084\u98df\u4e8b\u5236\u9650\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n

\u4e00\u65b9\u3001\u8fd1\u5e74\u306f\u30d1\u30c1\u30ed\u30de\u30fc\u3084SZC\u306e\u3088\u3046\u306a\u65b0\u85ac\u304c\u767b\u5834\u3057\u3001RAS\u963b\u5bb3\u85ac\u3084MRA\uff08\u6297\u30a2\u30eb\u30c9\u30b9\u30c6\u30ed\u30f3\u85ac\uff09\u3092\u7d99\u7d9a\u3059\u308b\u652f\u63f4\u7b56\u3068\u3057\u3066\u5927\u304d\u304f\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u904b\u52d5\u3084\u9069\u5207\u306a\u98df\u4e8b\u306e\u7d44\u307f\u5408\u308f\u305b\u3082\u542b\u3081\u305f\u7dcf\u5408\u7684\u306a\u7ba1\u7406\u306b\u3088\u308a\u3001CKD\u60a3\u8005\u306e\u751f\u6d3b\u306e\u8cea\u3084\u5fc3\u81d3\u30fb\u814e\u81d3\u306e\u4e88\u5f8c\u3092\u6539\u5584\u3057\u3088\u3046\u3068\u3059\u308b\u6d41\u308c\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3057\u304b\u3057\u3001\u9ad8\u4fa1\u306a\u85ac\u306e\u30b3\u30b9\u30c8\u8ca0\u62c5\u3084\u4fdd\u967a\u9069\u7528\u306e\u554f\u984c\u304c\u6b8b\u3063\u3066\u304a\u308a\u3001\u4eca\u5f8c\u306f\u81e8\u5e8a\u8a66\u9a13\u306e\u9577\u671f\u7684\u30c7\u30fc\u30bf\u3068\u3042\u308f\u305b\u3001\u793e\u4f1a\u5168\u4f53\u3067\u8cbb\u7528\u5bfe\u52b9\u679c\u306e\u8b70\u8ad6\u3092\u6df1\u3081\u308b\u5fc5\u8981\u304c\u3042\u308a\u305d\u3046\u3067\u3059\u3002<\/p>\n\n\n\n

\u4eca\u5f8c\u3082\u7814\u7a76\u306e\u84c4\u7a4d\u306b\u3088\u3063\u3066\u3001\u3088\u308a\u591a\u304f\u306e\u60a3\u8005\u304c\u5b89\u5168\u306b\u6cbb\u7642\u3092\u53d7\u3051\u3089\u308c\u308b\u74b0\u5883\u304c\u6574\u3046\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

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