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\u3000<\/p>\n\n\n\n

\u8d64\u30ef\u30a4\u30f3\u3092\u98f2\u3080\u3068\u3001\u982d\u75db\u304c\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u305b\u3093\u304b\uff1f\u767d\u30ef\u30a4\u30f3\u3084\u30d3\u30fc\u30eb\u3067\u306f\u554f\u984c\u306a\u3044\u306e\u306b\u3001\u8d64\u30ef\u30a4\u30f3\u3060\u3051\u304c\u982d\u75db\u3092\u5f15\u304d\u8d77\u3053\u3059\u306e\u306f\u306a\u305c\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n\n\n\n

\u3053\u308c\u306f\u9577\u5e74\u306e\u8b0e\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u6700\u65b0\u306e\u7814\u7a76\u304c\u3001\u8d64\u30ef\u30a4\u30f3\u306b\u591a\u304f\u542b\u307e\u308c\u308b\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306e\u4e00\u7a2e\u300c\u30b1\u30eb\u30bb\u30c1\u30f3<\/strong>\u300d\u304c\u982d\u75db\u306e\u539f\u56e0\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/strong><\/p>\n\n\n\n

\u30b1\u30eb\u30bb\u30c1\u30f3\u3068\u306f\uff1f<\/strong><\/p>\n\n\n\n

\u30b1\u30eb\u30bb\u30c1\u30f3\u306f\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u3068\u547c\u3070\u308c\u308b\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u5316\u5408\u7269\u306e\u4e00\u3064\u3067\u3001\u30d6\u30c9\u30a6\u306e\u679c\u76ae<\/strong>\u3001\u7389\u306d\u304e\u3001\u308a\u3093\u3054\u3001\u7dd1\u8336\u306a\u3069\u306b\u8c4a\u5bcc\u306b\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u6297\u9178\u5316\u4f5c\u7528\u304c\u3042\u308a\u3001\u5065\u5eb7\u7dad\u6301\u306b\u5f79\u7acb\u3064\u6210\u5206\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u8d64\u30ef\u30a4\u30f3\u306b\u306f\u767d\u30ef\u30a4\u30f3\u306e\u7d0410\u500d<\/strong>\u306e\u91cf\u306e\u30b1\u30eb\u30bb\u30c1\u30f3\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u4f53\u5185\u306b\u6442\u53d6\u3055\u308c\u305f\u30b1\u30eb\u30bb\u30c1\u30f3\u306f\u4ee3\u8b1d\u3055\u308c\u3001\u300c\u30b1\u30eb\u30bb\u30c1\u30f3-3-\u30b0\u30eb\u30af\u30ed\u30f3\u9178<\/strong>\u300d\u3068\u3044\u3046\u7269\u8cea\u306b\u5909\u5316\u3057\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u3053\u306e\u4ee3\u8b1d\u7269\u304c\u982d\u75db\u306e\u5f15\u304d\u91d1\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n

\u3000<\/strong><\/p>\n\n\n\n

\u30b1\u30eb\u30bb\u30c1\u30f3-3-\u30b0\u30eb\u30af\u30ed\u30f3\u9178\u3068ALDH2\u963b\u5bb3\u306e\u95a2\u4fc2<\/strong><\/p>\n\n\n\n

\u30a2\u30eb\u30b3\u30fc\u30eb\u306f\u4f53\u5185\u3067\u4ee3\u8b1d\u3055\u308c\u308b\u904e\u7a0b\u3067\u3001\u307e\u305a\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9<\/strong>\u3068\u3044\u3046\u6709\u5bb3\u7269\u8cea\u306b\u5909\u63db\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u3092\u7121\u5bb3\u306a\u9162\u9178\u306b\u5206\u89e3\u3059\u308b\u9175\u7d20\u304cALDH2\uff08\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u8131\u6c34\u7d20\u9175\u7d20\uff09<\/strong>\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u30b1\u30eb\u30bb\u30c1\u30f3-3-\u30b0\u30eb\u30af\u30ed\u30f3\u9178\u306fALDH2\u3092\u963b\u5bb3\u3057\u3001\u3053\u306e\u5206\u89e3\u904e\u7a0b\u3092\u59a8\u3052\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u30b1\u30eb\u30bb\u30c1\u30f3-3-\u30b0\u30eb\u30af\u30ed\u30f3\u9178\u306fALDH2\u306e\u6d3b\u6027\u3092\u6700\u592737%\u4f4e\u4e0b<\/strong>\u3055\u305b\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u304c\u5206\u89e3\u3055\u308c\u305a\u306b\u4f53\u5185\u306b\u84c4\u7a4d\u3057\u3001\u982d\u75db\u3084\u5410\u304d\u6c17\u306e\u539f\u56e0\u3068\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u30b1\u30eb\u30bb\u30c1\u30f3\u3092\u591a\u304f\u542b\u3080\u7389\u306d\u304e\u3084\u308a\u3093\u3054\u306a\u3069\u306e\u98df\u54c1\u3067\u306f\u3001\u982d\u75db\u306f\u8d77\u3053\u308a\u307e\u305b\u3093\u3002\u3053\u308c\u306f\u3001\u3053\u308c\u3089\u306e\u98df\u54c1\u306b\u30a2\u30eb\u30b3\u30fc\u30eb\u304c\u542b\u307e\u308c\u3066\u304a\u3089\u305a\u3001\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u304c\u751f\u6210\u3055\u308c\u306a\u3044\u305f\u3081\u3067\u3059\u3002<\/p>\n\n\n\n

\u3000<\/strong><\/p>\n\n\n\n

\u8d64\u30ef\u30a4\u30f3\u306b\u542b\u307e\u308c\u308b\u30b1\u30eb\u30bb\u30c1\u30f3\u91cf\u3068\u305d\u306e\u5f71\u97ff<\/strong><\/p>\n\n\n\n

\u4f8b\u3048\u3070\u3001\u8d64\u30ef\u30a4\u30f31\u676f\uff08\u7d04147ml\uff09\u306b\u306f\u3001\u7d0450.6\u03bcM\u306e\u30b1\u30eb\u30bb\u30c1\u30f3\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u98f2\u9152\u5f8c\u3001\u30b1\u30eb\u30bb\u30c1\u30f3\u306f\u8840\u4e2d\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3001\u305d\u306e\u6fc3\u5ea6\u306f\u6700\u59276\u03bcM\u306b\u9054\u3057\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u305d\u306e\u307b\u3068\u3093\u3069\u304c\u300c\u30b1\u30eb\u30bb\u30c1\u30f3-3-\u30b0\u30eb\u30af\u30ed\u30f3\u9178\u300d\u306b\u4ee3\u8b1d\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u6fc3\u5ea6\u306f\u3001ALDH2\u306e\u963b\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3059\u306e\u306b\u5341\u5206\u306a\u30ec\u30d9\u30eb\u3067\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u4e00\u65b9\u3001\u767d\u30ef\u30a4\u30f3\u3084\u30d3\u30fc\u30eb\u306f\u30b1\u30eb\u30bb\u30c1\u30f3\u306e\u542b\u6709\u91cf\u304c\u975e\u5e38\u306b\u5c11\u306a\u304f\u3001\u540c\u69d8\u306e\u982d\u75db\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u306f\u4f4e\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/strong><\/p>\n\n\n\n

\u4eca\u5f8c\u306e\u7814\u7a76\u3068\u5b9f\u7528\u7684\u306a\u5bfe\u7b56<\/strong><\/p>\n\n\n\n

\u73fe\u6642\u70b9\u3067\u306f\u3001\u30d2\u30c8\u3092\u5bfe\u8c61\u306b\u3057\u305f\u81e8\u5e8a\u8a66\u9a13\u304c\u5fc5\u8981\u3067\u3059\u304c\u3001\u4eca\u5f8c\u306e\u7814\u7a76\u3067\u306f\u3001\u4ee5\u4e0b\u306e\u70b9\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

    \n
  1. \u30b1\u30eb\u30bb\u30c1\u30f3\u542b\u6709\u91cf\u306e\u7570\u306a\u308b\u30ef\u30a4\u30f3\u306b\u3088\u308b\u982d\u75db\u767a\u751f\u7387\u306e\u6bd4\u8f03<\/li>\n\n\n\n
  2. ALDH2\u306e\u6d3b\u6027\u304c\u4f4e\u3044\u4f53\u8cea\uff08\u907a\u4f1d\u7684\u8981\u56e0\uff09\u3068\u306e\u95a2\u9023\u6027\u306e\u89e3\u660e<\/li>\n\n\n\n
  3. \u30ef\u30a4\u30f3\u4e2d\u306e\u30b1\u30eb\u30bb\u30c1\u30f3\u542b\u6709\u91cf\u3092\u7c21\u6613\u7684\u306b\u6e2c\u5b9a\u3059\u308b\u624b\u6cd5\u306e\u78ba\u7acb<\/li>\n<\/ol>\n\n\n\n

    \u305d\u306e\u3046\u3048\u3067\u3001\u5b9f\u7528\u7684\u306a\u5bfe\u7b56\u3068\u3057\u3066\u3001\u30b1\u30eb\u30bb\u30c1\u30f3\u542b\u6709\u91cf\u304c\u5c11\u306a\u3044\u30ef\u30a4\u30f3\u3092\u9078\u3076\u3053\u3068\u3067\u3001\u982d\u75db\u3092\u56de\u907f\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

    \u3000<\/strong><\/p>\n\n\n\n

    \u53c2\u8003\u6587\u732e\uff1a<\/strong><\/p>\n\n\n\n

    Devi, A., Levin, M. & Waterhouse, A.L. Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red wine headaches. Sci Rep<\/em> 13, 19503 (2023). https:\/\/doi.org\/10.1038\/s41598-023-46203-y<\/a><\/strong><\/p>\n\n\n\n

    \u3000<\/p>\n\n\n

    \n
    \"\"<\/figure>\n<\/div>\n\n\n

    <\/p>\n","protected":false},"excerpt":{"rendered":"

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