\u5f93\u6765\u306e\u6cbb\u7642\u6cd5\u306f\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u306e\u751f\u6210\u3092\u6291\u3048\u308b\u3053\u3068\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u7279\u5b9a\u306e\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u3067\u3042\u308b\u300c\u30a2\u30df\u30ed\u30a4\u30c9\u03b242\u300d\uff08A\u03b242\uff09\u3092\u5897\u3084\u3059\u3053\u3068\u3067\u6cbb\u7642\u52b9\u679c\u304c\u5f97\u3089\u308c\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n
\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u6297\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u6297\u4f53\u3068\u547c\u3070\u308c\u308b\u65b0\u3057\u3044\u6cbb\u7642\u85ac\u304c\u3001A\u03b242\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u3067\u8a18\u61b6\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3092\u6291\u3048\u3001\u81e8\u5e8a\u7684\u306a\u8870\u9000\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u304b\u3092\u8abf\u67fb\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n
\u3000<\/p>\n\n\n\n
\u7814\u7a76\u7d50\u679c\uff1a\u6570\u5024\u3067\u898b\u308b\u52b9\u679c<\/strong><\/p>\n\n\n\n \u3053\u306e\u7814\u7a76\u3067\u306f\u300124\u4ef6\u306e\u81e8\u5e8a\u8a66\u9a13\u300125,966\u4eba\u306e\u30c7\u30fc\u30bf\u3092\u5206\u6790\u3057\u3001\u4ee5\u4e0b\u306e\u52b9\u679c\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n \u3000<\/p>\n\n\n\n – A\u03b242<\/strong>\u306e\u5897\u52a0<\/strong><\/p>\n\n\n\n – \u9ac4\u6db2\u4e2d\u306eA\u03b242\u30ec\u30d9\u30eb\u306f\u6700\u5927\u7d041,300 pg\/ml\u5897\u52a0\u3002<\/p>\n\n\n\n – \u8a18\u61b6\u6a5f\u80fd\u3078\u306e\u52b9\u679c<\/strong><\/p>\n\n\n\n – \u8a18\u61b6\u6a5f\u80fd\u3092\u8a55\u4fa1\u3059\u308bADAS-Cog\u30b9\u30b3\u30a2\u306e\u4f4e\u4e0b\u3092\u6291\u5236\uff08RC = -0.55\uff0cP = 0.003\uff09\u3002<\/p>\n\n\n\n – \u81e8\u5e8a\u7684\u8870\u9000\u3078\u306e\u52b9\u679c<\/strong><\/p>\n\n\n\n – \u81e8\u5e8a\u9032\u884c\u3092\u8a55\u4fa1\u3059\u308bCDR-SB\u30b9\u30b3\u30a2\u306e\u4f4e\u4e0b\u3092\u6291\u5236\uff08RC = -0.16\uff0cP = 0.002\uff09\u3002<\/p>\n\n\n\n \u3000<\/p>\n\n\n\n A\u03b242\u306e\u5f79\u5272\u3068\u6cbb\u7642\u52b9\u679c<\/strong><\/p>\n\n\n\n A\u03b242\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306e\u6210\u9577\u3084\u53ef\u5851\u6027\u3092\u4fc3\u9032\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u6297\u9178\u5316\u4f5c\u7528\u3084\u795e\u7d4c\u4fdd\u8b77\u4f5c\u7528\u3092\u6301\u3064\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3067\u306f\u3001\u3053\u306eA\u03b242\u304c\u51dd\u96c6\u3057\u3066\u30a2\u30df\u30ed\u30a4\u30c9\u6591\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u3067\u3001\u8133\u5185\u306eA\u03b242\u6fc3\u5ea6\u304c\u4f4e\u4e0b\u3057\u307e\u3059\u3002<\/p>\n\n\n\n \u6297\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u6297\u4f53\u306f\u3001A\u03b242\u306e\u51dd\u96c6\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u305d\u306e\u6fc3\u5ea6\u3092\u56de\u5fa9\u3055\u305b\u3001\u795e\u7d4c\u7d30\u80de\u3092\u4fdd\u8b77\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u4eca\u5f8c\u306e\u5c55\u671b<\/strong><\/p>\n\n\n\n \u3053\u306e\u7814\u7a76\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066A\u03b242\u306e\u5897\u52a0\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u9032\u3080\u3053\u3068\u3067\u3001\u6297\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u6297\u4f53\u306e\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u89e3\u660e\u3055\u308c\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u53c2\u8003\u6587\u732e\uff1a<\/strong><\/p>\n\n\n\n Abanto J, Dwivedi AK, Imbimbo BP, Espay AJ. Increases in amyloid-\u03b242 slow cognitive and clinical decline in Alzheimer’s disease trials. Brain<\/em>. 2024;147(10):3513-3521. doi:10.1093\/brain\/awae216<\/strong><\/p>\n\n\n\n \u3000<\/p>\n\n\n \u3000<\/p>\n","protected":false},"excerpt":{"rendered":" \u3000 \u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08AD\uff09\u306f\u3001\u8a18\u61b6\u3084\u601d\u8003\u80fd\u529b\u3092\u596a\u3046\u9032\u884c\u6027\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3067\u3042\u308a\u3001\u4e16\u754c\u4e2d\u30675,000\u4e07\u4eba\u4ee5\u4e0a\u304c\u7f79\u60a3\u3057\u3001\u9ad8\u9f62\u5316\u793e\u4f1a\u306b\u304a\u3051\u308b\u5927\u304d\u306a\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002 \u3053\u306e\u75c5\u6c17\u306e\u9032\u884c\u306b\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u308b\u306e\u304c\u3001\u8133\u5185\u306b\u84c4\u7a4d\u3059…<\/p>\n","protected":false},"author":2,"featured_media":26113,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27,36],"tags":[],"class_list":["post-26111","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-27","category-36"],"jetpack_featured_media_url":"https:\/\/sakuda-clinic.com\/doctor\/wp-content\/uploads\/2024\/12\/middle-aged-woman-walking-2.jpg","jetpack_shortlink":"https:\/\/wp.me\/p3uEcz-6N9","jetpack-related-posts":[{"id":27542,"url":"https:\/\/sakuda-clinic.com\/doctor\/?p=27542","url_meta":{"origin":26111,"position":0},"title":"\u30a2\u30df\u30ed\u30a4\u30c9\u4eee\u8aac\u306e32\u5e74\u2015\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u7814\u7a76\u306e\u3086\u304f\u3048","author":"sakuda","date":"2025\/07\/05","format":false,"excerpt":"\u3000 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\u7d39\u4ecb\u3057\u305f\u8ad6\u6587\u306e\u97f3\u58f0\u6982\u8981\u3092\u3001NotebookLM\u3067\u30dd\u30c3\u30c9\u30ad\u30e3\u30b9\u30c8\u5316\u3057\u3066\u3044\u307e\u3059\u3002\u3042\u308f\u305b\u3066\u304a\u697d\u3057\u307f\u304f\u3060\u2026","rel":"","context":"\u5065\u5eb7","block_context":{"text":"\u5065\u5eb7","link":"https:\/\/sakuda-clinic.com\/doctor\/?cat=9"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/sakuda-clinic.com\/doctor\/wp-content\/uploads\/2025\/05\/later-age-at-onset-in-Parkinsons-disease-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/sakuda-clinic.com\/doctor\/wp-content\/uploads\/2025\/05\/later-age-at-onset-in-Parkinsons-disease-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/sakuda-clinic.com\/doctor\/wp-content\/uploads\/2025\/05\/later-age-at-onset-in-Parkinsons-disease-1.jpg?resize=525%2C300&ssl=1 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\u5916\u6765\u3067\u306f\u3001\u307b\u3068\u3093\u3069\u6905\u5b50\u306b\u5ea7\u3063\u3066\u8a3a\u7642\u3057\u3066\u3044\u307e\u3059\u304b\u3089\u3001\u30e9\u30f3\u30cb\u30f3\u30b0\u306e\u306a\u3044\u65e5\u306f2000\u6b69\u3082\u6b69\u3044\u3066\u3044\u306a\u3044\u6c17\u2026","rel":"","context":"\u5065\u5eb7","block_context":{"text":"\u5065\u5eb7","link":"https:\/\/sakuda-clinic.com\/doctor\/?cat=9"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/sakuda-clinic.com\/doctor\/wp-content\/uploads\/2025\/11\/Physical-activity-as-a-modifiable-risk-factor-in-preclinical-Alzheimers-disease.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/sakuda-clinic.com\/doctor\/wp-content\/uploads\/2025\/11\/Physical-activity-as-a-modifiable-risk-factor-in-preclinical-Alzheimers-disease.jpg?resize=350%2C200&ssl=1 1x, 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\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u8a8d\u77e5\u75c7\u3068\u3044\u3046\u8a00\u8449\u3092\u805e\u3051\u3070\u3001\u591a\u304f\u306e\u4eba\u2026","rel":"","context":"\u6587\u732e","block_context":{"text":"\u6587\u732e","link":"https:\/\/sakuda-clinic.com\/doctor\/?cat=27"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/sakuda-clinic.com\/doctor\/wp-content\/uploads\/2025\/07\/The-potential-dual-role-of-tau-phosphorylation.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/sakuda-clinic.com\/doctor\/wp-content\/uploads\/2025\/07\/The-potential-dual-role-of-tau-phosphorylation.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/sakuda-clinic.com\/doctor\/wp-content\/uploads\/2025\/07\/The-potential-dual-role-of-tau-phosphorylation.jpg?resize=525%2C300&ssl=1 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\u3068\u3053\u308d\u304c\u3001\u610f\u2026","rel":"","context":"\u30de\u30a4\u30f3\u30c9\u30d5\u30eb\u30cd\u30b9","block_context":{"text":"\u30de\u30a4\u30f3\u30c9\u30d5\u30eb\u30cd\u30b9","link":"https:\/\/sakuda-clinic.com\/doctor\/?cat=4"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/sakuda-clinic.com\/doctor\/wp-content\/uploads\/2026\/01\/A-Randomized-Clinical-Trial-Reveals-Effects-of-Mindfulness-and-Slow-Breathing-on-Plasma.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/sakuda-clinic.com\/doctor\/wp-content\/uploads\/2026\/01\/A-Randomized-Clinical-Trial-Reveals-Effects-of-Mindfulness-and-Slow-Breathing-on-Plasma.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/sakuda-clinic.com\/doctor\/wp-content\/uploads\/2026\/01\/A-Randomized-Clinical-Trial-Reveals-Effects-of-Mindfulness-and-Slow-Breathing-on-Plasma.jpg?resize=525%2C300&ssl=1 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