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\u3000<\/p>\n\n\n\n

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\u3053\u306e\u75c5\u6c17\u306f\u591a\u304f\u306e\u4eba\u306b\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u539f\u56e0\u3084\u767a\u751f\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u306f\u4f9d\u7136\u3068\u3057\u3066\u4e0d\u660e\u306a\u70b9\u304c\u591a\u3044\u306e\u304c\u73fe\u72b6\u3067\u3059\u3002<\/p>\n\n\n\n

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\u3000<\/p>\n\n\n\n

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\u305d\u306e\u4e2d\u306b\u306f\u3001\u8133\u5185\u306e\u7d30\u80de\u304c\u3069\u306e\u3088\u3046\u306b\u5909\u5316\u3059\u308b\u304b\u3092\u8a73\u7d30\u306b\u8ffd\u8de1\u3059\u308b\u7814\u7a76\u3082\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u4eca\u56de\u306f\u3001\u305d\u306e\u3088\u3046\u306a\u7814\u7a76\u304b\u3089\u5f97\u3089\u308c\u305f\u300c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u7d30\u80de\u5730\u56f3\u300d\u306b\u3064\u3044\u3066\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u300184\u540d\u306e\u63d0\u4f9b\u8005\u304b\u3089\u63a1\u53d6\u3057\u305f\u8133\u7d44\u7e54\u3092\u4f7f\u3044\u3001\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u306e\u5909\u5316\u3092\u8ffd\u8de1\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u5e73\u5747\u5e74\u9f62\u306f88\u6b73\u3067\u3001\u53c2\u52a0\u8005\u306f33\u540d\u304c\u7537\u6027\u300151\u540d\u304c\u5973\u6027\u3067\u3059\u3002<\/p>\n\n\n\n

\u7814\u7a76\u8005\u305f\u3061\u306f\u3001\u5358\u4e00\u6838RNA\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\uff08snRNA-seq\uff09\u306a\u3069\u306e\u6700\u65b0\u6280\u8853\u3092\u99c6\u4f7f\u3057\u3001\u8133\u306e\u4e2d\u9593\u5074\u982d\u56de\uff08MTG\uff09\u3068\u3044\u3046\u90e8\u4f4d\u3092\u89e3\u6790\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3053\u306e\u90e8\u4f4d\u306f\u8a00\u8a9e\u3084\u8a18\u61b6\u306b\u6df1\u304f\u95a2\u308f\u308b\u91cd\u8981\u306a\u9818\u57df\u3067\u3059\u3002<\/p>\n\n\n\n

\u7d50\u679c\u3068\u3057\u3066\u3001340\u4e07\u500b\u4ee5\u4e0a\u306e\u6838\u3092\u89e3\u6790\u3057\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u9032\u884c\u306b\u4f34\u3044\u7d30\u80de\u304c\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u53d7\u3051\u308b\u306e\u304b\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u305d\u306e\u7d50\u679c\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u9032\u884c\u306b\u306f\u5927\u304d\u304f\u4e8c\u3064\u306e\u6bb5\u968e\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

– \u65e9\u671f\u75c5\u671f<\/strong>\u3067\u306f\u3001\u708e\u75c7\u6027\u30df\u30af\u30ed\u30b0\u30ea\u30a2\uff08\u514d\u75ab\u7d30\u80de\u306e\u4e00\u7a2e\uff09\u3084\u53cd\u5fdc\u6027\u661f\u72b6\u7d30\u80de\uff08\u8133\u5185\u306e\u30b5\u30dd\u30fc\u30c8\u7d30\u80de\uff09\u304c\u5897\u52a0\u3057\u3001\u7279\u306b\u30bd\u30de\u30c8\u30b9\u30bf\u30c1\u30f3\u3092\u6301\u3064\u6291\u5236\u6027\u30cb\u30e5\u30fc\u30ed\u30f3\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u524d\u99c6\u7d30\u80de\uff08OPCs\uff09\u304c\u795e\u7d4c\u306e\u7d76\u7e01\u4f53\u3067\u3042\u308b\u9ac4\u9798\u3092\u518d\u751f\u3057\u3088\u3046\u3068\u3059\u308b\u6d3b\u52d5\u3082\u898b\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

– \u5f8c\u671f\u75c5\u671f<\/strong>\u306b\u9032\u3080\u3068\u3001\u75c5\u7406\u7684\u306a\u5909\u5316\u304c\u6025\u6fc0\u306b\u9032\u884c\u3057\u3001\u8208\u596e\u6027\u30cb\u30e5\u30fc\u30ed\u30f3\u3084Pvalb+\u304a\u3088\u3073Vip+\u3068\u547c\u3070\u308c\u308b\u7279\u5b9a\u306e\u6291\u5236\u6027\u30cb\u30e5\u30fc\u30ed\u30f3\u304c\u5927\u5e45\u306b\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

\u3053\u308c\u3089\u306e\u767a\u898b\u304b\u3089\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u5358\u306b\u8133\u306e\u4e00\u90e8\u304c\u640d\u50b7\u3092\u53d7\u3051\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u7d30\u80de\u3054\u3068\u306b\u7570\u306a\u308b\u53cd\u5fdc\u3092\u793a\u3059\u8907\u96d1\u306a\u30d7\u30ed\u30bb\u30b9\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

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\u3000<\/p>\n\n\n\n

\u305d\u306e\u75be\u60a3\u306b\u5bfe\u3059\u308b\u7406\u89e3\u3092\u6df1\u3081\u308b\u3053\u3068\u306f\u3001\u3053\u306e\u75c5\u6c17\u3068\u5411\u304d\u5408\u3046\u305f\u3081\u306e\u7b2c\u4e00\u6b69\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

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\u3000<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/p>\n\n\n\n

Gabitto MI, Travaglini KJ, Rachleff VM, Kaplan ES, Long B, Ariza J, Ding Y, Mahoney JT, Dee N, Goldy J, Melief EJ, Brouner K, Campos J, Carr AJ, Casper T, Chakrabarty R, Clark M, Compos J, Cool J, Valera Cuevas NJ, Dalley R, Darvas M, Ding SL, Dolbeare T, Mac Donald CL, Egdorf T, Esposito L, Ferrer R, Gala R, Gary A, Gloe J, Guilford N, Guzman J, Ho W, Jarksy T, Johansen N, Kalmbach BE, Keene LM, Khawand S, Kilgore M, Kirkland A, Kunst M, Lee BR, Malone J, Maltzer Z, Martin N, McCue R, McMillen D, Meyerdierks E, Meyers KP, Mollenkopf T, Montine M, Nolan AL, Nyhus J, Olsen PA, Pacleb M, Pham T, Pom CA, Postupna N, Ruiz A, Schantz AM, Sorensen SA, Staats B, Sullivan M, Sunkin SM, Thompson C, Tieu M, Ting J, Torkelson A, Tran T, Wang MQ, Waters J, Wilson AM, Haynor D, Gatto N, Jayadev S, Mufti S, Ng L, Mukherjee S, Crane PK, Latimer CS, Levi BP, Smith K, Close JL, Miller JA, Hodge RD, Larson EB, Grabowski TJ, Hawrylycz M, Keene CD, Lein ES. Integrated multimodal cell atlas of Alzheimer’s disease. Res Sq [Preprint]. 2023 May 23:rs.3.rs-2921860. doi: 10.21203\/rs.3.rs-2921860\/v1. PMID: 37292694; PMCID: PMC10246227.<\/strong><\/p>\n\n\n\n

\u3000<\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

\u3000<\/p>\n","protected":false},"excerpt":{"rendered":"

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